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1

Sotorasib Targeted Therapy for Metastatic Breast Cancer with KRAS G12C+ Brain Metastases

BrainMet ADePPT (Anticancer Drug Penetration Platform Trial)

Purpose: To find out how safe and effective sotorasib, an experimental targeted therapy, is at treating KRAS G12C+ brain tumors.

Who is this for?: People with metastatic (stage IV) breast cancer that has spread to the brain (brain metastasis) who are planning to receive brain surgery. Brain metastases must be KRAS G12C positive (KRAS G12C+). View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sotorasib</li></ul>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Sotorasib is an experimental targeted therapy called a KRAS G12C inhibitor. Blocking KRAS G12C may slow or stop cancer cells from growing.</li> <li class="seamTextUnorderedListItem">Sotorasib has been approved for other types of cancer. Its use in this trial is considered experimental.</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06807619' target='_blank'>ClinicalTrials.gov</a> </li><li class='seamTextUnorderedListItem'><a href='https://mbcbrainmets.org/' target='_blank'>MBCBrainMets.org</a> </li><li class='seamTextUnorderedListItem'><a href='https://www.onclive.com/view/dr-fakih-on-the-fda-approval-of-sotorasib-plus-panitumumab-for-kras-g12c-mutated-mcrc' target='_blank'>OncLive: Sotorasib for KRAS G12C+ Colorectal Cancer</a> </li></ul>
1

Sotorasib Targeted Therapy for Metastatic Breast Cancer with KRAS G12C+ Brain Metastases

BrainMet ADePPT (Anticancer Drug Penetration Platform Trial)
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Nearest Location:
2539 miles
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
Basking Ridge, NJ

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Visits:
Number of visits unavailable

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ClinicalTrials.gov: NCT06807619

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Phase I

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