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1

Brodalumab to Manage Immunotherapy Side Effects for People with Advanced Breast Cancer

Safety and Efficacy of Brodalumab in the Treatment of Immune-Related Adverse Events: a Pilot Study

Purpose: To study the safety and ability of brodalumab to manage side effects from immunotherapy.

Who is this for?: People with advanced (some stage III) or metastatic (stage IV) breast cancer who are experiencing side effects from immunotherapy. View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Brodalumab, by injection, weekly for 3 weeks, then every 2 weeks for 5.5 months</li> <li class="seamTextUnorderedListItem">Steroids (if needed)</li> <li class="seamTextUnorderedListItem">CT scan, 3 times within 6 months</li> <li class="seamTextUnorderedListItem">Questionnaires</li></ul>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Cancer immunotherapy can cause side effects.</li> <li class="seamTextUnorderedListItem">Side effects from immunotherapy can be similar to symptoms of autoimmune conditions.</li> <li class="seamTextUnorderedListItem">Brodalumab is FDA approved to treat people with autoimmune diseases (diseases where the immune system is activated against normal organs), and safe doses and treatment schedules have been determined in these people.</li> <li class="seamTextUnorderedListItem">Therefore, this trial will study the use of brodalumab to manage immunotherapy side effects.</li> <li class="seamTextUnorderedListItem">In this trial, the use of brodalumab is considered experimental.</li> <li class="seamTextUnorderedListItem">In this trial, visits will be a combination of in-person and virtual.</li> <li class="seamTextUnorderedListItem">A computed tomography (CT) scan produces body pictures created by x-ray energy.</li> <li class="seamTextUnorderedListItem">This trial is also enrolling people with other types of cancer.</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT06673329' target='_blank'>ClinicalTrials.gov</a> </li></ul>
1

Brodalumab to Manage Immunotherapy Side Effects for People with Advanced Breast Cancer

Safety and Efficacy of Brodalumab in the Treatment of Immune-Related Adverse Events: a Pilot Study
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Nearest Location:
2569 miles
Columbia University Irving Medical Center
New York, NY

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Visits:
1 visit every 1-2 weeks for 6 months

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ClinicalTrials.gov: NCT06673329

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Phase I

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