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NCT06518057
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Radiation to Reduce Side Effects for People with Metastatic Breast Cancer with Leptomeningeal Metastases

A Multi-Center Phase 2 Study of Hippocampal Avoidance in Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumors

Purpose: To study if radiation to the brain and spinal cord is an effective treatment while also reducing side effects for people with leptomeningeal metastases.

Who is this for?: People with metastatic (stage IV) breast cancer that has spread to the leptomeninges (leptomeningeal disease). View full eligibility criteria

What's involved?

You will receive the following:

  • Radiation to brain and spinal cord, 10 times within 2 weeks
  • Lumbar puncture to collect CSF
  • CT scans
  • MRI scans
  • Questionnaires, 4 times in 1 year

What's being studied?

  • Radiation therapy can reduce symptoms of leptomeningeal metastases.
  • However, the type of radiation therapy typically used does not prevent the spread of leptomeningeal disease.
  • Craniospinal irradiation (CSI) is radiation therapy directed at the brain and spinal cord. It may be able to target all potential areas of leptomeningeal tumor spread.
  • It may also reduce side effects of radiation because it avoids the part of the brain called the hippocampus.
  • Cerebrospinal fluid (CSF) is the fluid that surrounds your brain and spinal cord. CSF is typically collected during a procedure called a lumbar puncture, also known as a spinal tap.
  • A computed tomography (CT) scan produces body pictures created by x-ray energy.
  • A magnetic resonance imaging (MRI) scan produces body pictures created by using magnetic energy rather than x-ray energy.
  • This trial is also enrolling people with other types of cancer.

How can I learn more?

1

Radiation to Reduce Side Effects for People with Metastatic Breast Cancer with Leptomeningeal Metastases

A Multi-Center Phase 2 Study of Hippocampal Avoidance in Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumors
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Nearest Location:
682 miles
Fred Hutch/University of Washington Cancer Consortium
Seattle, WA

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Visits:
10 visits within 2 weeks

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ClinicalTrials.gov: NCT06518057

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Phase II

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