You have matched to 1 trial

Guest Profile:  No profile selected

Copy link
Sort by zip code: 94107 Hide Map Icon
mail-icon

Register to sign up for Trial Alerts

Receive emails about new trials that match your profile.
1

Estradiol Hormone Therapy and Olaparib Targeted Therapy for Postmenopausal Women with Advanced ER+, HER2- Breast Cancer

Phase 1b Study of Olaparib and Estradiol in Advanced ER+ Breast Cancer (PHOEBE)

Purpose: To study the safety, best dose, and effects (good and bad) of olaparib (Lynparza®) PARP inhibitor with estradiol (Estrace®) hormone therapy.

Who is this for?: Postmenopausal women with advanced (some stage III) or metastatic (stage IV) estrogen receptor positive (ER+), HER2 negative (HER2-) breast cancer who have received at least 1 line of hormone therapy for advanced disease. View full eligibility criteria

What's involved?

<p class="seamTextPara"> You will receive the following: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®), by mouth, daily for 2 months</li> <li class="seamTextUnorderedListItem">17b-estradiol (Estrace®), by mouth, daily for 2 months</li> </ul> <p class="seamTextPara"> followed 2 months later by: </p> <ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Estradiol (Estrace®), by mouth, daily</li></ul>

What's being studied?

<ul class="seamTextUnorderedList"> <li class="seamTextUnorderedListItem">Olaparib (Lynparza®) is a type of targeted therapy called a PARP inhibitor. PARP inhibitors work by blocking the action of poly (ADP-ribose) polymerase, an enzyme that helps repair DNA.</li> <li class="seamTextUnorderedListItem">Estradiol (Estrace®) is a type of hormone therapy for advanced ER+ breast cancer.</li></ul>

How can I learn more?

<ul class='seamTextUnorderedList'><li class='seamTextUnorderedListItem'>View eligibility criteria and additional trial information: <a href='https://clinicaltrials.gov/ct2/show/NCT05900895' target='_blank'>ClinicalTrials.gov</a> </li></ul>
1

Estradiol Hormone Therapy and Olaparib Targeted Therapy for Postmenopausal Women with Advanced ER+, HER2- Breast Cancer

Phase 1b Study of Olaparib and Estradiol in Advanced ER+ Breast Cancer (PHOEBE)
Icon

Nearest Location:
2619 miles
Dartmouth Cancer Center
Lebanon, NH

Icon

Visits:
Number of visits unavailable

Icon

ClinicalTrials.gov: NCT05900895

Icon

Phase I

HELP GUIDE
HELP GUIDE